He should be very suspicious! In this instance, though, there is no poison, magical potion, or laxative included. Or, at least, if there is, Loki didn't put it there.

"It's probably from some version of Faerie," he says. "Wouldn't work nearly so well, otherwise."

Usually, it takes him a dedicated effort to get drunk, even on Asgard's spirits. "I have had only two full glasses," he says, holding a hand up to indicate the size of the beverages he's consumed. "Along with a sampling of more mundane liquors, most Midgardian and therefore not nearly strong enough. It does have a kick."